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Public release date: 25-Sep-2012
Share ] Contact: Elaine Schmidt
eschmidt@mednet.ucla.edu
310-794-2272
University of California - Los Angeles Health Sciences
Watch out, acne. Doctors soon may have a new weapon against zits: a harmless virus living on our skin that naturally seeks out and kills the bacteria that cause pimples.
The Sept. 25 online edition of the American Society for Microbiology's mBio publishes the findings by scientists at UCLA and the University of Pittsburgh.
"Acne affects millions of people, yet we have few treatments that are both safe and effective," said principal investigator Dr. Robert Modlin, chief of dermatology and professor of microbiology, immunology and molecular genetics at the David Geffen School of Medicine at UCLA. "Harnessing a virus that naturally preys on the bacteria that causes pimples could offer a promising new tool against the physical and emotional scars of severe acne."
The scientists looked at two little microbes that share a big name: Propionibacterium acnes, a bacterium thriving in our pores that can trigger acne; and P. acnes phages, a family of viruses that live on human skin. The viruses are harmless to humans, but programmed to infect and kill the aforementioned P. acnes bacteria.
When P. acnes bacteria aggravate the immune system, it causes the swollen, red bumps associated with acne. Most effective treatments work by reducing the number of P. acnes bacteria on the skin.
"We know that sex hormones, facial oil and the immune system play a role in causing acne, however, a lot of research implicates P. acnes as an important trigger," explained first author Laura Marinelli, a UCLA postdoctoral researcher in Modlin's laboratory. "Sometimes they set off an inflammatory response that contributes to the development of acne."
Using over-the-counter pore cleansing strips from the drugstore, the researchers lifted acne bacteria and the P. acnes viruses from the noses of both pimply and clear-skinned volunteers.
When the team sequenced the bacteriophages' genomes, they discovered that the viruses possess multiple features such as small size, limited diversity and the broad ability to kill their hosts that make them ideal candidates for the development of a new anti-acne therapy.
"Our findings provide valuable insights into acne and the bacterium that causes it," observed corresponding author Graham Hatfull, Eberly Family Professor of Biotechnology, professor of biological sciences at the University of Pittsburgh and a Howard Hughes Medical Institute researcher. "The lack of genetic diversity among the phages that attack the acne bacterium implies that viral-based strategies may help control this distressing skin disorder."
"Phages are programmed to target and kill specific bacteria, so P. acnes phages will attack only P. acnes bacteria, but not others like E. coli," added Marinelli. "This trait suggests that they offer strong potential for targeted therapeutic use."
Acne affects nearly 90 percent of Americans at some point in their lives, yet scientists know little about what causes the disorder and have made narrow progress in developing new strategies for treating it. Dermatologists' arsenal of anti-acne tools -- benzoyl peroxide, antibiotics and Accutane hasn't expanded in decades.
"Antibiotics such as tetracycline are so widely used that many acne strains have developed resistance, and drugs like Accutane, while effective, can produce risky side effects, limiting their use," explained coauthor Dr. Jenny Kim, director of the UCLA Clinic for Acne, Rosacea and Aesthetics. "Acne can dramatically disfigure people and undermine their self-esteem, especially in teens. We can change patients' lives with treatment. It's time we identified a new way to safely treat the common disorder."
The research team plans to isolate the active protein from the P. acnes virus and test whether it is as effective as the whole virus in killing acne bacteria. If laboratory testing proves successful, the researchers will study the compound's safety and effectiveness in combating acne in people.
###
The study was supported by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (R21AR060382, R01 AR053542 and F32AR060655) at the National Institutes of Health in Bethesda, Md.
Additional coauthors included Sorel Fitz-Gibbon, Megan Inkeles, Shawn Cokus, Matteo Pellegrini and Jeffrey F. Miller, all of UCLA; former UCLA researchers Clarmyra Hayes and Anya Loncaric, now of the California Institute of Technology and Solta Medical, respectively; and Charles Bowman, Daniel Russell and Deborah Jacobs-Sera of the University of Pittsburgh.
The Clinic for Acne, Rosacea and Aesthetics at the UCLA Division of Dermatology at the David Geffen School of Medicine offers comprehensive care for acne and rosacea, as well as the scarring and discoloration that can result from these conditions. The clinic's goal is to educate the public and help patients develop habits leading to healthy skin. Current research projects include studying the effect of Vitamin-D on immune response to acne, the effect of Omega-3 fatty acids on acne and its treatment, and the use of a mobile device application for acne management. To schedule an appointment, call (310) 825-6911.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 25-Sep-2012 Share ] Contact: Elaine Schmidt
eschmidt@mednet.ucla.edu
310-794-2272
University of California - Los Angeles Health Sciences
Watch out, acne. Doctors soon may have a new weapon against zits: a harmless virus living on our skin that naturally seeks out and kills the bacteria that cause pimples.
The Sept. 25 online edition of the American Society for Microbiology's mBio publishes the findings by scientists at UCLA and the University of Pittsburgh.
"Acne affects millions of people, yet we have few treatments that are both safe and effective," said principal investigator Dr. Robert Modlin, chief of dermatology and professor of microbiology, immunology and molecular genetics at the David Geffen School of Medicine at UCLA. "Harnessing a virus that naturally preys on the bacteria that causes pimples could offer a promising new tool against the physical and emotional scars of severe acne."
The scientists looked at two little microbes that share a big name: Propionibacterium acnes, a bacterium thriving in our pores that can trigger acne; and P. acnes phages, a family of viruses that live on human skin. The viruses are harmless to humans, but programmed to infect and kill the aforementioned P. acnes bacteria.
When P. acnes bacteria aggravate the immune system, it causes the swollen, red bumps associated with acne. Most effective treatments work by reducing the number of P. acnes bacteria on the skin.
"We know that sex hormones, facial oil and the immune system play a role in causing acne, however, a lot of research implicates P. acnes as an important trigger," explained first author Laura Marinelli, a UCLA postdoctoral researcher in Modlin's laboratory. "Sometimes they set off an inflammatory response that contributes to the development of acne."
Using over-the-counter pore cleansing strips from the drugstore, the researchers lifted acne bacteria and the P. acnes viruses from the noses of both pimply and clear-skinned volunteers.
When the team sequenced the bacteriophages' genomes, they discovered that the viruses possess multiple features such as small size, limited diversity and the broad ability to kill their hosts that make them ideal candidates for the development of a new anti-acne therapy.
"Our findings provide valuable insights into acne and the bacterium that causes it," observed corresponding author Graham Hatfull, Eberly Family Professor of Biotechnology, professor of biological sciences at the University of Pittsburgh and a Howard Hughes Medical Institute researcher. "The lack of genetic diversity among the phages that attack the acne bacterium implies that viral-based strategies may help control this distressing skin disorder."
"Phages are programmed to target and kill specific bacteria, so P. acnes phages will attack only P. acnes bacteria, but not others like E. coli," added Marinelli. "This trait suggests that they offer strong potential for targeted therapeutic use."
Acne affects nearly 90 percent of Americans at some point in their lives, yet scientists know little about what causes the disorder and have made narrow progress in developing new strategies for treating it. Dermatologists' arsenal of anti-acne tools -- benzoyl peroxide, antibiotics and Accutane hasn't expanded in decades.
"Antibiotics such as tetracycline are so widely used that many acne strains have developed resistance, and drugs like Accutane, while effective, can produce risky side effects, limiting their use," explained coauthor Dr. Jenny Kim, director of the UCLA Clinic for Acne, Rosacea and Aesthetics. "Acne can dramatically disfigure people and undermine their self-esteem, especially in teens. We can change patients' lives with treatment. It's time we identified a new way to safely treat the common disorder."
The research team plans to isolate the active protein from the P. acnes virus and test whether it is as effective as the whole virus in killing acne bacteria. If laboratory testing proves successful, the researchers will study the compound's safety and effectiveness in combating acne in people.
###
The study was supported by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (R21AR060382, R01 AR053542 and F32AR060655) at the National Institutes of Health in Bethesda, Md.
Additional coauthors included Sorel Fitz-Gibbon, Megan Inkeles, Shawn Cokus, Matteo Pellegrini and Jeffrey F. Miller, all of UCLA; former UCLA researchers Clarmyra Hayes and Anya Loncaric, now of the California Institute of Technology and Solta Medical, respectively; and Charles Bowman, Daniel Russell and Deborah Jacobs-Sera of the University of Pittsburgh.
The Clinic for Acne, Rosacea and Aesthetics at the UCLA Division of Dermatology at the David Geffen School of Medicine offers comprehensive care for acne and rosacea, as well as the scarring and discoloration that can result from these conditions. The clinic's goal is to educate the public and help patients develop habits leading to healthy skin. Current research projects include studying the effect of Vitamin-D on immune response to acne, the effect of Omega-3 fatty acids on acne and its treatment, and the use of a mobile device application for acne management. To schedule an appointment, call (310) 825-6911.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-09/uoc--gvt092012.php
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Source: http://6thwardalderman.com/reliable-advice-to-get-you-by-means-of-payday-loan-borrowing/
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Everyone wants to pay less tax right?
To do that you need to know what you can claim? and what you can?t.??
It?s not about cheating the system, or creative accounting.??
It?s all about claiming what you?re entitled to.?
That?s why we?ve developed the Is it Deductible checklist.
Click on here to download a PDF version.
?
Item | ? |
Admission Fees For lawyers and other professionals. Disallowed as capital cost. | O |
Airport Lounge Membership Deductions to the extent used for work-related purposes. | P |
Annual Practicing Certificate: Applies to professional persons and other contractors who must pay an annual fee to practice in their chosen field.? | P |
Bank Charges: Deductions are allowed if account earns interest. Not private transaction fees. | P |
Briefcase: If used for work and/or business purposes the cost is fully deductible if $300 or less. If more than $300, it must be depreciated. | P |
Calculators and Electronic Organisers: If used for work and/or business purposes the cost is fully deductible if $300 or less. If more than $300, it must be depreciated. | P |
Child Care Fees | O |
Clothing, Uniforms and Footwear: ??????? Compulsory uniform: Uniform must be unique and particular to an organization (e.g. Corporate uniform) ??????? Non-Compulsory uniform: If on a register kept by the Department of Industry, Science and Tourism. ??????? Occupational specific: The clothing identifies a particular trade, vocation or profession (e.g. Chefs and nurses) ??????? Protective: Must be used to protect the person or their conventional clothing. May include sunscreen. | P |
Club Membership Fees | O |
Coaching Classes: Allowed to performing artists to maintain existing skills or obtain related skills | P |
Computer and Software: Software is deductible if it costs less than $300, otherwise deductible over 2.5 years. Except in-house developed software which is over 4 years from 1 July 2008. | P |
Conferences, Seminars and Training Courses: Allowed if designed to maintain or increase employee?s knowledge, skills or ability. | P |
Item | ? |
Conventional Clothing | O |
Depreciation: Tools, equipment, and plant used for work purposes for each item costing more than $300. Items costing $300 or less are deductible outright in the year of acquisition. | P |
Driver?s Licence: Cost of acquiring and renewing. | O |
Dry Cleaning: Allowed if the cost of the clothing is also deductible. See also ?Laundry?. | P |
Entertainment Expenses | O |
Fines: Imposed by court, or under law of Commonwealth, State, Territory of foreign country (s26-5). | O |
First Aid Course: Provided it is directly related to employment or business activities. | P |
Gaming Licence: Hospitality industry. | P |
Gifts / Donations of $2 or more If made to approved ?deductible gift recipient? body or fund. See ato.gov.au for a full list. Gifts to clients are deductible if employees can demonstrate a direct connection with earning assessable income. | P |
Glasses and contact lenses (prescribed): These would qualify as medical expenses. Deductible if ?protective clothing?. | O |
Glasses and Goggles: Protective only. | P |
Grooming | O |
HELP/HECS Repayments | O |
Home Office Expenses: If you perform some of your work from your home office, you may be able to claim a deduction for the costs you incur in running your home office. ? Running? Expenses:? For? example,? electricity,? gas? and? depreciation? of office? furniture? (e.g. desk,? tables,? chairs,? cabinets,? shelves, professional library). ? Occupancy Expenses: For example, rent, insurance, rates and land tax. Deductible only to the extent that home or study is used as a place of business. | P |
Income Protection Insurance: Allowed only if the proceeds are assessable. | P |
Insurance ? sickness or accident: When benefits would be assessable income. | P |
Interest: Allowed if money borrowed for work-related purposes or to finance income earning assets. Interest paid on underpayment of tax (e.g. General interest charge) is deductible. Fines and administrative penalties are not deductible. Interest on capital protection loans deductible except for non-deductible capital protection component. | P |
Item | ? |
Internet and Computer Equipment: Expenses allowed to the extent incurred in deriving individual?s work-related income, carrying on a business or earning investment income (e.g. share investing). | P |
Laundry and Maintenance: Allowed if the cost of clothing is allowable (see ?work related clothing?). Reasonable claims of up to $150 do not need to be substantiated. | P |
Legal Expenses: Renewal of existing employment contract. | P |
Meals: | ? |
? Eaten during normal working day | O |
? Meals acquired when travelling overnight for work-related purpose | P |
? Meals when travelling (not overnight). | O |
? Overtime Meals: If allowance received under award | P |
Medical Examination: Only if from the referral of a work-related business licence | P |
Newspapers: Claims may be allowed in limited cases if the publication is directly related to income-producing activities. | O |
Overtime Meal Expenses: Only if award overtime meal allowance received. | P |
Parking Fees and Tolls: Includes bridge and road tolls (but not fines) paid while travelling for work-related purposes. | P |
Photographs (performing arts): | ? |
? Cost of maintaining portfolio | P |
? Cost of preparing portfolio | O |
Practising Certificate: Applies to professional employees. | P |
Prepaid Expenses: Non-business individuals and SBE taxpayers claim is fully deductible if services are to be performed in period not exceeding 12 months. All other taxpayers must apportion claim over the period of service | P |
Professional Association Fees | P |
Professional Library (books, CDs, videos etc): Establishedlibrary(depreciationallowed) | ? |
? New books: Full claim if cost $300 or less (includes a set if total cost is $300 or less). | P |
? New books: Depreciation if cost over $300 (includes a set if total cost is more than $300). | P |
Protective Equipment: Includes harnesses, goggles, safety glasses, breathing masks, helmets, boots. Claims for sunscreens, sunglasses and wet weather gear allowed if used to provide protection from natural environment. | P |
Item | ? |
Removal and Relocation Costs: If paid by the employer, may be exempt from FBT, but deductible. | O |
Repairs: Income producing property / or work-related equipment. | P |
Self-education costs: Claims for fees, books, travel (see below) and equipment etc. only if allowed if there is a direct connection between the course and the person?s income earning activities. No claim for the first $250 if course is undertaken at school or other educational institution and the course confers a qualification. However, that first $250 can be offset against private expenses, eg. travel, child minding fees, etc | P |
Seminars: Including conference and training courses if sufficiently connected to work activities. | P |
Social Functions | O |
Stationery: Diaries, log books etc. | P |
Subscriptions: | ? |
? Publications if a direct connection between publication end income earned by taxpayer. | P |
? Professional associations: Maximum of $42 if no longer gaining assessable income from that profession. | P |
? Sports clubs | O |
Sun Protection: Claims for sunglasses, hats and sunscreen allowed for taxpayers who work outside (see 12.147). | P |
Superannuation Contributions: Claims allowed in respect of employees. Substantially self-employed persons if their assessable income, reportable fringe benefits plus reportable employer superannuation? contributions is less than 10% of their total assessable income from all sources, reportable fringe benefits plus reportable employer superannuation contributions total. No deduction is available for interest on borrowed monies used to finance deductible personal superannuation contributions. | P |
Tax Agent Fees: (deduction can be claimed in the income year the expense is incurred). ? Travel and accommodation expenses if for travel to a tax agent or other recognised tax adviser to obtain tax advice, have returns prepared, be present at audit or object against an assessment. ? Cost of other incidentals if incurred in having tax return prepared, lodging an objection or appeal or defending an audit. | P |
Technical And Professional Publications | P |
Telephones and Other Telecommunications Equipment: (Including mobiles, pagers and beepers.) Cost of telephone calls (related to work purposes). | P |
? Installation or connection | O |
? Rental charges (if ?on call? or required to use on regular basis). | P |
? Silent telephone number. | O |
Tools: (work related only) If cost is $300 or less. ? If cost more than $300, the amount would be depreciable, and the amount deductible equals to the decline in value. | P |
Trauma Insurance: If benefits capital in nature. | O |
Travel Expenses: Including public transport, motor vehicles and motor cycles, fares, accommodation, meals and incidentals. Travel between home and work. | O |
? Where employee has no usual place of employment (e.g. travelling salesperson). | P |
? If ?on call?. | O |
? If actually working before leaving home (e.g. doctor giving instructions over phone from home. Note that this applies in limited circumstances only). | P |
? Must transport bulky equipment (e.g. builder with bulky tools) | P |
? Travel from home (which is a place of business) to usual place of employment | O |
? Travel from home to alternate work place (for work-related purposes) and return to normal work place (or directly home) | P |
? Travel between normal work place and alternate place of employment (or place of business) and return (of directly home) | P |
? Travel between two work places | P |
? Travel in course of employment: See Substantiation rules at 12.210 | P |
? Travel accompanied by relative (may be allowed if relative is also performing work-related duties) | O |
Union and Professional Association Fees | P |
Vaccinations | O |
Watch: Unless job specific such as a nurse?s job watch. | O |
?
For more information on any of the
above items, please contact your accountant at
Leader Accountancy
Office: Suite 207, 250 McCullough St, sunny bank, QLD 4109
T: 07 3727 8822 | F: 07 3727 8899 | E: jerry@leaderaccountancy.com.au
Source: http://leaderaccountancy.com.au/2012/09/is-it-tax-deductible/
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I can answer this question: when a major NYC branded hotel holds a 50th birthday celebration and there is no food, no wine, no spirits and only a small birthday cake served with even smaller bottles of water.
First The Invite
The e-invitation came from the PR representative of a very large NYC hotel (1780 rooms). Celebrating the birthdays of others is one of my favorite things: Count me in!
Hotel Parties are Usually Over-the-Top
I love hotel parties. Chefs, motivated to pull out their best wines and spirits provide dazzling displays; creative culinary treats are stacked on large tables with stiff white cloths; staff members, on their best behavior, wear sparkling clean uniforms or party clothes. Between the balloons, and happy music, hotel parties are frequently the best!
Anticipating a fun-filled afternoon and evening, I turned down a ribbon-cutting ceremony for a new building, a meeting with a colleague, and a dental appointment. I thought about wearing something sparkling with stilettos ? but the event started at 2:00 pm, and I thought it was a bit early for sequins and feathers. Oh yes, another reason to censor an elaborate frock - I was taking the subway (north) from Tribeca.
I Weep from Disappointment
Let me make sure the facts are correct: the invitation was for a 50th birthday party; however, there was no wine/spirits? in fact, there was no beverage bar at all (not a Coke or Diet Pepsi in sight). There were no hors d?oeuvres (not even little frankfurters in pastry blankets). There were no cheese platters, not even cheez-wiz with saltines, not a slice of cold pizza or a stale cookie. There was no food! Has anyone been to a birthday party where there was no food and nothing to drink?
In the speech read by the General Manager of the hotel (the highlight of the program), I learned that the birthday date was actually the following week, but everyone would be busy hosting the Clintons and heads of state so this was really a pre-birthday program. It is true that this hotel regularly hosts movie stars and government bigwigs as well as the hoi polloi who come to New York for conventions and sales calls. The hotel claims high occupancy and advertises high room rates (standard rooms start at US$329 and club rooms begin at US$699 per night). Do not forget to add US$14.95 per day for a Wi-Fi fee. With these rates, high occupancy and Wi-Fi fees, I thought there would be enough money in the till to put on a good party; it appears that I was wrong.
Clues
If I had not been caught up with the fantasy of sipping a glass of chilled champagne while munching on a large succulent shrimp in mid-afternoon, I would have zoned in on the early warning signs of an approaching disaster. First of all, this is not a hotel noted for its restaurants, bars, coffee shops, or catered affairs. This is first and foremost a commercial property. It is definitely my fault that I did not fully register the pervasive smell of McDonald?s fries and Big Macs in the lobby that grabbed my nose as I entered the hotel lobby. Any hotel that does not flush food aromas out of the public space is not looking to establish its competitive advantage as a gourmet dining establishment.
Rushing through the lobby, I passed the check-in counter (looked more like an airport check-in than a hotel portal) and I kept walking until I finally spotted a small cluster of people lingering behind a small red-roped area. Was this birthday-party central I asked. ?Yes.?
I did a quick scan of the small space at the tail-end of the hotel lobby and wondered where the party guests were located. Where were the decorations, the bar and the food? Maybe, I thought optimistically, the guests were being held in the lobby, because the party room set-up was not completed. Perhaps it was more efficient to gather everyone in the lobby.
Sadly, what I saw ? was all there was - nothing but a large flat cake with Happy Birthday scripted in frosting.
Since I was really thirsty (and hungry from inhaling the Mickey D aroma) ? I asked for a glass of wine or a Diet Coke, PLEASE! ?No!? The only thing I could have was a seat! So I sat and waited for the program to begin.
Although I arrived on time, the program was to be delayed. Once again I gave the organization the benefit of the doubt! The goodies were going to be wheeled in, along with the party hats and favors and maybe a clown or two. Wrong again.
When a Birthday Bash includes a Speech
The ?party? started with a speech read by the General Manager and was followed by the identification of three employees who had spent 50 years of their lives with the hotel. The next low-keyed OMG was the acknowledgement of a food and beverage staffer who had carved a replica of the hotel in wax. This big project was followed by a round of applause for the Chef and welcome remarks by a representative from the Office of the Mayor who read parts of the Proclamation from the City of New York. The event ended with a bit of cake and a small bottle of water for the media, NYC and Co representatives, and assorted hotel employees.
What Next?
For those of us with a need to find a story, the public relations staff offered a tour of the newly-renovated rooms. I was motivated to join the group when I spied one of the staffers with a frosty cup of iced Starbucks coffee. I thought that if I went for the tour my reward would be an iced beverage; once again I was disappointed. Even when we visited the Executive Lounge where beverages were available for the guests, there was nothing for me!
So, What is New?
There might be renovated bathrooms, but shower curtains and no-name amenities make the space less than wonderful. The new window treatments and wall-to-wall carpet provide an aroma that might be classified as toxic for people with allergies; however, I am not a scientist so this is purely conjecture. What I do know is that I got a headache as soon as I entered the rooms and took a deep breath. The Executive Lounge is quite comfortable, and we spotted one guest sprawled out on a couch watching television. Clearly the fellow was at ease ? he was tall and the couch was long enough for him to stretch out, full-length.
We took a tour of the Health Club that is located on a level below-ground level. There may be a fee to use the machines; the costs are based on accommodations reserved. The space hosts a series rooms with a variety of machines plus an exercise room that could also be used as a closet if storage becomes a problem. An attractive display of guest towels was perhaps the highlight of this part of the tour.
A-List
This week the Clinton?s, the President of Egypt, and other senior-level executives and politicos will be staying at the hotel. I spotted lots of exposed wires (that looked like a safety hazard to me), but I was told that the electricians were setting up systems to cover the event.
This is also the ?real? week for the hotel?s birthday. Perhaps the former President, his wife and others who are A-listed will be treated to a real birthday party. I hope they will have a glass of champagne for me.
Source: http://www.eturbonews.com/31311/when-birthday-party-not-party
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